鄭至玉 副教授兼系主任

研究領域 Research Interests 目前研究的方向包括：

(一)內切與外切幾丁質水解酵素的研究與改質：

(二)生化整治技術---利用酵素處理汙染物：

(三)甲殼素材料應用與開發

吳秉翰、蔡承恩、何筱君、翁佑璿、黃祐瑄、呂浩民、鄭至玉(指導老師)「用蘑法開啟永續降解新路徑 Mushroom Goodless 」2025教育部精準健康產業跨領域人才培育計畫之精準農業領域推動中心創新創業競賽 銀獎 2025/08/01

吳秉翰、張涵宇、陳鋒、蔡承恩、鄭至玉(指導老師)「用菇解毒，玩出永續新玩法！」113-2 校園創意發想提案競賽 提案入圍 2025/5/13

陳鋒、張涵宇、蔡承恩、吳秉翰、鄭至玉(指導老師)「菇類培養的雙引擎：生物降解與培養技術的融合創新與觀光教育」2025年第五屆Living Lab Project Awards永續生活實驗室獎 第二名2025/06/14

吳秉翰、張涵宇、蔡承恩、翁佑璿、鄭至玉(指導老師)「菇類培養的雙引擎：生物降解與培養技術的融合創新與觀光教育」114年度教育部「精準健康產業跨領域人才培育計畫」高科大創新創業競賽暨成果發表 第一名2025/06/11

Fisherman' s Best Friend ( FBF)，FDI 團隊 (王呈祐、蔡逸薰、張芳青、蘇詠捷、洪翊愷) 2024年教育部精準健康產業跨領域人才培育計劃準農業領域教學推動中心-創新創業競 銀獎 2024/8/1 (指導老師：蘇豐傑、蔡志明、鄭至玉) 新興式機能性飲料，Myco-life 菌昇生技(王重良、閔聖華、蔡承恩) 2023教育部精準健康產業跨領域人才培育計畫之精準農業領域教學推動中心-創新創業競賽 佳作 2023/8/3

Sidra Bibi, Zhong-Liang Wang, Chitsan Lin, Sheng-Hua Min, Chih-Yu Cheng*(2022) Optimization of Ganoderma Pellets Production as a Vegan Food Using the Plackett Burman Design and Taguchi Techniques. 10th International Forum on Industrial Bioprocessing (IBA-IFIBiop 2022) 2022/10/27~30, National Kaohsiung University of Science & Technology, Taiwan. p181. (Best Paper Award) 

閔聖華、王重良、林鈞緯、鄭至玉「白色工藝--廢棄農材的再利用」-Myco-life團隊，三環區域產業創新論壇(Ⅱ) 樹德科大 110/12/20 閔聖華、王重良、林鈞緯、鄭至玉「白色工藝--廢棄農材的再利用」2021年張昭鼎紀念基金會-永續發展創意發想競賽佳作

閔聖華、王重良、陳婕玗、Sidra Bibi、鄭至玉「SDGs: Myco-life」第2屆聯合國永續發展目標SDGs青年倡議英文提案競賽入圍獎，高科大應用英語系主辦 2021/11/3 

閔聖華、陳婕玗、郭家鴻、王重良、彭崇裕、鄭至玉「殼不殼以丟棄」2021向海致敬海洋探索短片競賽第三名，高科大主辦  2021/6/9 

王重良「靈芝菌絲球的最適化生產與價值開發」2021年海生系實務專題競賽第二名

王重良、閔聖華、鄭至玉「新興式食品--靈芝波霸的密集化培養條件與開發」2021年全國技專校院學生實務專題製作競賽佳作，教育部， 2021/6/11 

鄭雨薇、黃靖婷、陳威志、鄭至玉 「把海洋帶回家」2019/12/4 108-1校園創意發想提案競賽-海洋特色類 優選獎

Chih-Yu Cheng*, Zhi-Feng Zhang , Acharee Kaewlaoyoong and Chitsan Lin (2019) Improved Bioremediation on PCDD/Fs Contaminated Soil by Free-Mycelium Liquid Produced with Agro-industrial Residues. Novel idea in bioremediation: poster award. CESE-2019, 11/3-7, Taiwan.

陳師睿、鄭筑云、鄭至玉「當方塊君愛上維他命C」高科大創新創業實務專題商品化加值補助 2018/11/27 

林欣儀、陳師睿、鄭筑云、黃文彥、鄭至玉「甲殼三醣，去你的高血壓」高科大創新創業實務專題商品化加值補助 2018/11/27

陳詩予、柳佩君、鄭至玉「幾丁質止血材料與初步活體測試結果」 2013/5 國立高雄海洋科技大學水圈學院學生實務專題競賽 (研究所組 第三名)

蔡嘉煌、陳詩予、柳佩君、鄭至玉 「芽孢桿菌屬甲殼素水解酶Ala174/Leu175殘基之作用對產物分布」2012臺灣幾丁質幾丁聚醣學會年會暨幾丁聚醣奈米生技研討會暨海峽兩岸幾丁質幾丁聚醣研討會 台灣基隆 2012/7/13 (壁報論文 化學組佳作)

康文欣、柳佩君、鄭至玉「C型肝炎病毒之奈米探針製作及應用 」2012/4 國立高雄海洋科技大學水圈學院學生實務專題競賽(學士組 第三名)

辜宜婷、王智緯、鄭至玉「利用奈米磁性粒子結合白點症病毒vp28尋找vp28之結合蛋白」2012/4 國立高雄海洋科技大學水圈學院學生實務專題競賽(研究所組 佳作)

Nguyen, O. T. K., Chen, P. T., Nargotra, P., Chen, S. C., Cheng, C. Y., Wang, H. M. D., ... & Kuo, C. H. (2025). Sustainable bacterial chitosanase production using soybean meal hydrolysate: Insights into biochemical and hydrolysis characteristics. Process Biochemistry, 150, 202-212.  2025/03

Cheng, C. Y. *, Wang, Y. S., Wang, Z. L., & Bibi, S. (2023). Innovative Approaches to Fungal Food Production: Mycelial Pellet Morphology Insights. Foods, 12(18), 3477. https://doi.org/10.3390/foods12183477 (SCI 2023:5.56)

Cheng, C. Y. *, Zhang, Z. F., Kaewlaoyoong, A., Huang, J. T., Cheruiyot, N. K., Lin, C., & Huang, H. C. (2023). Improved bioremediation of PCDD/Fs contaminated soil by mycelium-free liquids induced by agro-industrial residues. Bioresource Technology Reports, 101435.

Bibi, S., Wang, Z. L., Lin, C., Min, S. H., & Cheng, C. Y.* (2023). Two-stage cultivation strategies for optimal production of Ganoderma pellets with potential application in the vegan food industry. Journal of Food Science and Technology, 60:1793-1802. 

Huang, C. J., Peng, H. L., Patel, A. K., Singhania, R. R., Dong, C. D.*, & Cheng, C. Y.* (2021). Effects of lower temperature on expression and biochemical characteristics of HCV NS3 antigen recombinant protein. Catalysts, 11(11), 1297.

Chen, S. T., Chien, H. W., Cheng, C. Y., Huang, H. M., Song, T. Y., Chen, Y. C., ... & Ou, S. F. (2021). Drug-release dynamics and antibacterial activities of chitosan/cefazolin coatings on Ti implants. Progress in Organic Coatings, 159, 106385.

Kaewlaoyoong, A., Chen, J. R., Cheng, C. Y., Lin, C., Cheruiyot, N. K., & Sriprom, P. (2021). Innovative mycoremediation technique for treating unsterilized PCDD/F-contaminated field soil and the exploration of chlorinated metabolites. Environmental Pollution, 289, 117869.

Cheng, C. Y.*, Tsai, C. H., Liou, P. J., & Wang, C. H. (2021). Pilot-Scale Production of Chito-Oligosaccharides Using an Innovative Recombinant Chitosanase Preparation Approach. Polymers, 13(2), 290.https://doi.org/10.3390/polym13020290 

Hsueh, Y. H., Cheng, C. Y., Chien, H. W., Huang, X. H., Huang, C. W., Wu, C. H., ... & Ou, S. F. (2020). Synergistic effects of collagen and silver on the deposition characteristics, antibacterial ability, and cytocompatibility of a collagen/silver coating on titanium. Journal of Alloys and Compounds, 830, 154490.

黃弘州與鄭至玉(2020)大學生社團服務學習營隊夥伴關係研究：以被服務者的觀點論之。學生事務與輔導59卷1期 (2020 / 06 / 01) P30 – 46  10.6506/SAGC.202006_59(1).0004

Kaewlaoyoong, A., Cheng, C. Y., Lin, C., Chen, J. R., Huang, W. Y., & Sriprom, P. (2020). White rot fungus Pleurotus pulmonarius enhanced bioremediation of highly PCDD/F-contaminated field soil via solid state fermentation. Science of The Total Environment, 738, 139670. https://doi.org/10.1016/j.scitotenv.2020.139670.

Cheng, C. Y*., Juei, Y. S., Liou, P. J., & Ku, Y. T. (2018). Utilization and development of modified chitosan in cosmetic products. 臺灣水產學會刊, 45(4), 209-217. DOI： 10.29822/JFST.201812_45(4).0001 

Yi-Hsuan Huang, Wen-Jen Yang, Chih-Yu Cheng, Huang-Mo Sung and Shuen-Fuh Lin^∗ (2017) Bostrycin production by agro-industrial residues and its potential for food processing. Food Sci. Biotechnol. 26(3): 715–721.  https://doi.org/10.1007/s10068-017-0082-6

Chih-Yu Cheng, Chia-I. Liao and Shuen-Fuh Lin^∗ (2015) Borate-fructose complex: A novel mediator for laccase and its new function for fructose determination. FEBS letters 589(20):3107-3112.

Wen-Ming Chen, Rey-Chang Chang, Chih-Yu Cheng, Yu-Wen Shiau, Shih-Yi Sheu (2013) Jeongeupia chitinilytica sp. nov., a chitinolytic bacterium isolated from soil in Taiwan. Int J Syst Evol Microbiol. 63(Pt3):934-8

Cheng-Fu Chao, Yi-Yun Chen, Chih-Yu Cheng^∗∗ and Yaw-Kuen Li∗ (2013) Catalytic function of a newly purified exo-beta-d-glucosaminidase from the entomopathogenic fungus Paecilomyces lilacinus. Carbohydrate Polymers 93(2): 615–621

Chen WM, Yang SH, Huang WC, Cheng CY, and Sheu SY. (2012) Chitinivorax tropicus gen. nov., sp. nov., a chitinolytic bacterium isolated from a freshwater lake. Int J Syst Evol Microbiol. 62(Pt5):1086-91

CJ Huang, HL Peng*, and CY Cheng* (2011) Improving antigenicity of the recombinant hepatitis C virus core protein via random mutagenesis. J Biomed Biotechnol. Vol. 2011, Article ID 359042, 6 pages doi:10.1155/2011/359042

Yang CS, Sheu SY, Young CC, Arun AB, Cheng CY, and Chen WM. (2010) Chitinibacter alvei sp. nov., isolated from stream water. Int J Syst Evol Microbiol. 60(Pt8):1760-4.

Chen WM, Chung YN, Chiu TF, Cheng CY, Arun AB, and Sheu SY. (2010) Deefgea chitinilytica sp. nov., isolated from a wetland.  Int J Syst Evol Microbiol 60(Pt 6):1450-3.

Chang KS, Luo L, Chang CW, Huang YC, Cheng CY, Hung CS, Diau EW, and Li YK. (2010) Novel Steroid-Sensing Model and Characterization of Protein Interactions Based on Fluorescence Anisotropy Decay (double dagger). J Phys Chem B: 114(12):4327-34.

Wu YJ, Cheng CY* and Li YK* (2009) Cloning and Expression of Chitinase A from Serratia marcescens for Large-scale Preparation of N,N-Diacetyl Chitobiose.   J. Chin. Chem. Soc-Taip. 56(4):688-695.

Yao YY, Shrestha KL, Wu YJ, Tasi HJ, Chen CC, Yang JM, Ando A, Cheng CY*, and Li YK* (2008) Structural simulation and protein engineering to convert an endo-chitosanase to an exo-chitosanase. Protein Eng Des Sel.  21(9):561-566. 

Cheng CY, Chang CH, Wu YJ, and Li YK* (2006) Exploration of Glycosyl Hydrolase Family 75, a Chitosanase from Aspergillus fumigatus.  J. Biol. Chem. 281:3137-3144.
 

Chih-Yu Cheng, invited speaker: Reprogramming Chitosanase Specificity via the ChiTuned™ Platform: From Simulation to Selection, One Platform, One Trimer.  30^th BEST Conference & International Symposium on Biotechnology and Biochemical Engineering 2025/6/26-28 NKUST, Kaohsiung, Taiwan.

Sidra Bibi, Cheng-En Cai, Chih-Yu Cheng, Optimizing Pleurotus sp. Pellet Morphology and Biomass Production: A Taguchi Method Approach with Image Analysis. 30^th BEST Conference & International Symposium on Biotechnology and Biochemical Engineering 2025/6/26-28 NKUST, Kaohsiung, Taiwan. (Honorable Mention Award)

Han-Yu Chang, Asami Yoshida, Kiyoshi Osatomi, Chih-Yu Cheng, Chitooligosaccharides Produced by Engineered Enzymes Induce Selective Anticancer Activity. 30^th BEST Conference & International Symposium on Biotechnology and Biochemical Engineering 2025/6/26-28 NKUST, Kaohsiung, Taiwan.

Chih-Yu Cheng*, Sheng-Hua Min, Cheng-En Cai, Bing-Han Wu, and Fong Chen (2024) Sustainability Concept of Future Food: Screening and Cultivating Colorful Mycelial Pellets.  The 29th Symposium of Young Asian Biological Engineers’ Community (YABEC-2024) 2024/10/17-19.  Arpina, Busan, Republic of Korea.     

Sheng-Hua Min^#, Cheng-En Cai, Bing-Han Wu, Chih-Yu Cheng* (2024) Future Food: Submerged Culture and Preparation of Lepista Sordida Mycelium Pellets. 2024 BEST Conference & International Symposium on Biotechnology and Biochemical Engineering 2024/6/21-23 BEST Penghu, Taiwan. 

Sheng-Hua Min*, Kai-Yung Chen, Cheng-En Cai, Chiu-Wen Chen and Chih-Yu Cheng* ( 2024) Optimization of Ganoderma Fungi-algae Pellets Preparation and Their Applications in Aquariums.台灣水產學會 113 年度學術論文發表會暨會員大會 2024/1/16 國立屏東科技大學 (海報佳作獎)

Shang-Hui-Chung, Chih-Yu Cheng*, Cheng-Di Dong, and Bao-Le Quach (2023) Mitigating Disease Challenges in Asian Shrimp Aquaculture: The Efficacy of Shuanghuanglian Formulation Interventions. 第 38 屆天然藥物研討會—從歷史中洞察天然物暨藥學及中醫藥學學門成果發表會The 38th Symposium on Natural Products—Insights into Natural Products from History & Symposium on Pharmacy and Traditional Chinese Medicine 2023/10/27~10/29, Fu Jen Catholic University, Taiwan. P201.

Sidra Bibi, Zhong-Liang Wang, Chitsan Lin, Sheng-Hua Min, Chih-Yu Cheng*(2022) Optimization of Ganoderma Pellets Production as a Vegan Food Using the Plackett Burman Design and Taguchi Techniques. 10th International Forum on Industrial Bioprocessing (IBA-IFIBiop 2022) 2022/10/27~30, National Kaohsiung University of Science & Technology, Taiwan. p181. (Best Paper Award)

Sheng-Hua Min, Ju-Yun Hsu, Yu-Ru Zhang, Chih-Yu Cheng* (2022) Screening, preparation, and application of fungi-algae pellet-a new type of aquarium decorative feeds. 10th International Forum on Industrial Bioprocessing (IBA-IFIBiop 2022) 2022/10/27~30, National Kaohsiung University of Science & Technology, Taiwan. P179.

Sidra Bibi, Inam Ullah, Chitsan Lin, and Chih-Yu Cheng* (2021). Water use efficiency and field performance of some selected wheat genotypes of Pakistan. (oral presentation), The 26th Symposium of Young Asian Biological Engineers’ Community (YABEC-2021) 2021/11/17~20. Chiaki Ogino, Kobe University, Japan A.

Hussain, C. Lin and C. -Y. Cheng, "Synthesis of g-C3N4 by doping Bi2S3 for the photocatalytic degradation of NOx under solar light," 2021 International Symposium on Intelligent Signal Processing and Communication Systems (ISPACS), 2021, pp. 1-2, doi: 10.1109/ISPACS51563.2021.9651005.

Zhong-Liang Wang and Chih-Yu Cheng* (2021) Production optimization of Ganoderma mycelial pellets using Taguchi method. The 26th BEST Conference & International Symposium on Biotechnology and Bioengineering (BEST-2021) 2021/10/01~02 (student: oral presentation), National Chung Hsing University Taichung City, Taiwan.

Yu-Sheng Wang and Chih-Yu Cheng* (2021) Optimization of Pleurotus Pellet Production by Plackett-Burman Design Combined with Taguchi Method. The 26th BEST Conference & International Symposium on Biotechnology and Bioengineering (BEST-2021) 2021/10/01~02, National Chung Hsing University Taichung City, Taiwan.

Chih-Yu Cheng*, Zhi-Feng Zhang, Jing-Ting Huang, Acharee Kaewlaoyoong and Chitsan Lin (2019) Characterization and potential of extracellular multi-enzymes of Phanerochaete chrysosporium for bioremediation of PCDD/Fs. The 25th Symposium of Young Asian Biological Engineers’Community (YABEC-2019), 2019/11/22~24,  Ewha Womans University, Seoul, Korea.

Chih-Yu Cheng*, Zhi-Feng Zhang, Acharee Kaewlaoyoong and Chitsan Lin. (2019) Improved Bioremediation on PCDD/Fs Contaminated Soil by Free-Mycelium Liquid Produced with Agro-industrial Residues. Challenges in Environmental Science and Engineering (CESE-2019), 2019/11/3~8, National Kaohsiung University of Science & Technology, Taiwan. p122

黃靖婷、李品柔、黃弘州、Mario Jens Hansen、鄭至玉 (2019) 漆酶生產菌菇之篩選、酵素生產與其最適反應活性條件分析.真菌學術研討會暨 108年度真菌學會年會, 2019/11/2, 台北. P35

Mario Jens Hansen, Chih-Yu Cheng* and Jenq-Renn Chen (2019) Morphological and molecular based species recognition reveals progress in description of Hypomyces amaurodermatis (Hypocreales, Ascomycota) in Taiwan. 真菌學術研討會暨 108年度真菌學會年會, 2019/11/2, 台北. p39

Chi-Hang Wang and Chih-Yu Cheng* (2018) The modification of Bacillus circulans MH-K1 chitosanase and its application for large-scale preparation of chitotriose. 14th International Chitin and Chitosan Conference (14th ICCC) & 12th Asia-Pacific Chitin and Chitosan Symposium (12th APCCS) 2018/8/27~2018/8/30, Senriyama Campus of Kansai University, Osaka, Japan. 2018:24(2):332

You-Ying Chen, Ting-Shan Yang, Heny-Ling Chu, Chih-Yu Cheng, Rey-Chang Chang (2016). Study on the Antioxidant activity and Cytotoxicity of Trionychidae (Pelodiscus Sinensis) Protein hydrolysate. January 19, 2016. 屏科大 Annual Meeting for the Fisheries Society of Taiwan (National Symposium Poster).

Chih-Yu Cheng* and Pei-Jyun Liou (2015) Double mutation of A174/L175 and T180/G181on Bacillus chitosanase and its effect on hydrolysate distribution. The 21th Symposium of Young Asian Biochemical Engineers' Community YABEC2015 Oct 14-16/2015, Chuncheon, Korea. pp. 23.

Heuy-Ling Chu, Ting-Shan Yang, Chih-Yu Cheng and Rey-Chang Chang (2015). Study on Isolation and Antioxidant activity of Trionychida (Pelodiscus Sinensis) Bioactive peptides. July 16-19, 2015. IFT (Istitute of Food Technologists) Annual meeting & food Exp.,Chicage, IL USA (International Symposium Poster)

Pei-Jyun Liou, Chia-Huang Tasi, Hann-Ii Wu, Chi-Hang Wang, and Chih-Yu Cheng* (2014, Nov) An efficient strategy from high-throughput in-situ screening, efficient purification to large-scale preparation of chitooligosaccharides. The 20th Symposium of Young Asian Biochemical Engineers' Community YABEC2014 Nov 6-8/2014, Chiayi, Taiwan. pp. 100.

Chih-yu Cheng* and Chia-Huang Tsai (2013, Aug). Effects of exo-loop and Ala174/Leu175 on hydrolysate distribution of Bacillus chitosanase. The 19 th Symposium of Young Asian Biochemical Engineers' Community, 8/7/2013-8/9/2013, Urumqi, Xinjiang, China. pp.159。

蔡嘉煌、陳詩予、柳佩君、鄭至玉^* 「芽孢桿菌屬甲殼素水解酶Ala174/Leu175殘基之作用對產物分布」臺灣幾丁質幾丁聚醣學會年會暨幾丁聚醣奈米生技研討會暨海峽兩岸幾丁質幾丁聚醣研討會 台灣基隆 2012/7/13 (壁報論文 化學組佳作)

Tsai CH, Liou PJ, and Cheng CY* “An efficient purification of recombinant Bacillus chitosanase and its application for large-scale preparation of chitosan oligosaacharide” The 9th Asia-Pacific Chitin and Chitosan Symposium (9th APCCS), 2011/8/3-2011/8/6, Nha Trang, Vietnam. (NKMU)

Cheng CY“Investigation of endo- and exo-type of hydrolase by protein structure simulation” Stanford University Stanford, U.S.A. August 14-15, 2010 The 10th Emerging Information and Technology Conference (EITC-2010) (oral presentation)(NKMU)

Chung YN, Chen WM, Chiu TF, Cheng CY, Arun AB, and Sheu SY* “Deefgea chitinilytica sp. nov., isolated from wetland in Taiwan.”  11th International Conference on Chitin and Chitosan and the 8th Asia-Pacific Chitin and Chitosan Symposium, Taipei, Taiwan, Sep. 6-9 2009 第11屆國際幾丁質幾丁聚醣學術研討會(11th ICCC)暨第8屆幾丁質幾丁聚醣學術研討會

Chang SW, Chung YN, Juei YS, Sheu SY, Cheng CY* “Chitin or chitosan hydrolysate detection on plate.”  11th International Conference on Chitin and Chitosan and the 8th Asia-Pacific Chitin and Chitosan Symposium, Taipei, Taiwan, Sep. 6-9 2009 第11屆國際幾丁質幾丁聚醣學術研討會(11th ICCC)暨第8屆幾丁質幾丁聚醣學術研討會( NSC 98-2313-B-022-003-)

Cheng CY *, Li YK, Juei YS, Wu YJ, Yao YY  “Investigation of endo- and exo-type of chitosanase by protein structure simulation” 9th International Conference of The European Chitin Society, Venice, Italy, May 23-26 2009 (NSC 97-2311-B-022-001-MY2)

Yao YY, Shrestha KL, Tasi HJ, Chen CC, Yang JM, Ando A, Cheng CY* and Li YK* “Structural Simulation and Protein Engineering for Converting an Endo-chitosanae to an Exochitosanase”  2008台灣幾丁質與幾丁聚醣國際研討會, Tainan, Taiwan. May 16, 2008. (NSC 97-2311-B-022-001-MY2)

Wu YJ, Cheng CY, Li YK “Marcescens Chi A for large-scale preparation of N,N-diacetyl chitobiose and Chi A mutant for N-acetyl glucosamine” 2008台灣幾丁質與幾丁聚醣國際研討會, Tainan, Taiwan. May 16, 2008. (NSC 97-2311-B-022-001-MY2)

鄭至玉*、李耀坤、吳岳進、姚月雲、蔡三進 「以蛋白質結構探討甲殼素水解酵素之內切與外切特性」2007兩岸航運暨漁業論壇 台灣高雄 2007/12/25 (oral presentation)

Yao YY, Tasi HJ, Wu YJ, Cheng CY, Ando A and Li YK “Structural Simulation and Protein Engineering for Converting an Endo-chitosanase to Exo-chitosanase” 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress. Kyoto, Japan, June 18-23, 2006.